- 作者：Florian Hucke ; Wolfgang Sieghart ; Matthias Pinter ; Ivo Graziadei ; Wolfgang Vogel ; Christian M眉ller ; Harald Heinzl ; Fredrik Waneck ; Michael Trauner ; Markus Peck-Radosavljevic
- 关键词：Hepatocellular carcinoma ; TACE ; Prognosis ; HCC ; ART score
- 刊名：Journal of Hepatology
- 出版年：January, 2014
- 年：2014
- 卷：60
- 期：1
- 页码：118-126
- 全文大小：959 K
Background & Aims
Recently, we developed the ART score (assessment for re-treatment with TACE) to guide the decision for a second transarterial chemoembolization (TACE-2) in patients with hepatocellular carcinoma (HCC). Patients with an ART score of 0-1.5 points gained benefit from a second TACE session, while patients with an ART score 猢?.5 points did not.Here, we investigated (1) the prognostic significance of the ART score prior to the third (TACE-3) and fourth TACE (TACE-4), and (2) the feasibility of an ART score guided re-treatment strategy by sequential assessment of the ART score in HCC patients treated with multiple TACE sessions.
Methods
109 patients, diagnosed with intermediate stage HCC and treated with 猢? TACE sessions between January 1999 and December 2009 at the Medical Universities of Vienna and Innsbruck, were included. The ART score prior to each TACE session was assessed in comparison to the TACE na茂ve liver. The prognostic performance of the ART score before TACE-3 and 4 was evaluated with and without stratification based on the ART score prior to the respective last intervention.
Results
The pre-TACE-3 ART score discriminated two groups with different prognosis and remained a valid predictor of OS independent of Child-Pugh score (5-7 points), CRP-levels and tumor characteristics. Even in patients with an initially beneficial ART score (0-1.5 points) before TACE-2, repeated ART score assessment before TACE-3 identified a subgroup of patients with dismal prognosis (median OS: 27.8 vs. 10.8 months, p <0.001). Similar results were observed when the ART score was applied before TACE-4.
Conclusions
The sequential assessment of the ART score identifies patients with dismal prognosis prior to each TACE session.