Biocompatible polysaccharide-based cryogels
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- 作者：Senta Reichelt ; Jana Becher ; J眉rgen Weisser ; Andrea Prager ; Ulrich Decker ; Stephanie M枚ller ; Albrecht Berg ; Matthias Schnabelrauch
- 关键词：Cryogel ; Electron-beam ; Cell cultivation ; Biocompatibility ; Polysaccharides
- 刊名：Materials Science and Engineering: C
- 出版年：1 February, 2014
- 年：2014
- 卷：35
- 期：Complete
- 页码：164-170
- 全文大小：833 K
文摘
This study focuses on the development of novel biocompatible macroporous cryogels by electron-beam assisted free-radical crosslinking reaction of polymerizable dextran and hyaluronan derivatives. As a main advantage this straightforward approach provides highly pure materials of high porosity without using additional crosslinkers or initiators. The cryogels were characterized with regard to their morphology and their basic properties including thermal and mechanical characteristics, and swellability. It was found that the applied irradiation dose and the chemical composition strongly influence the material properties of the resulting cryogels. Preliminary cytotoxicity tests illustrate the excellent in vitro-cytocompatibility of the fabricated cryogels making them especially attractive as matrices in tissue regeneration procedures.