Biotechnology and sustainability: the role of transatlantic cooperation in research and innovation
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- 作者：Alfredo Aguilar ; Laurent Bochereau ; Line Matthiessen-Guyader
- 关键词：Electrophilic sugars ; Michael reactions ; Electrophilicity index-based QSAR ; Enhanced electrophilicity
- 刊名：Trends in Biotechnology
- 出版年：2008
- 出版时间：April 2008
- 年：2008
- 卷：26
- 期：4
- 页码：163-165
- 全文大小：84 K
文摘
The global electrophilicity index that incorporates electrostatic and polarizability contributions shows a quantitative correlation with antiviral and cytotoxic activities of electrophilic sugars. The model is applied to a series of compounds that behave as Michael acceptors in interaction with biological nucleophilic targets.