Morbidity of Focal Therapy in the Treatment of Localized Prostate Cancer

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• 作者：Eric Barret^a ; ^{eric.barret@imm.fr} ; Youness Ahallal^a ; Rafael Sanchez-Salas^a ; Marc Galiano^a ; Jean-Marc Cosset^a ; Pierre Validire^b ; Petr Macek^a ; Matthieu Durand^a ; Dominique Prapotnich^a ; Franç ; ois Rozet^a ; Xavier Cathelineau^a
• 关键词：Morbidity ; Prostate cancer ; Focal therapy
• 刊名：European Urology
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：63
• 期：4
• 页码：618-622
• 全文大小：122 K

文摘

Background

Focal therapy (FT) for prostate cancer (PCa) seems to be part of a natural evolution in the quest to improve the management of early organ-confined disease.

Objective

To assess the morbidity of the initial experience of FT in a tertiary referral center for PCa management.

Design, setting, and participants

From 2009 to 2011, a total of 1213 patients with clinically localized PCa were treated at our institution. Of these patients, 547 were considered to have indolent disease according to the D¡¯Amico criteria for low-risk disease plus unilateral disease with a maximum of three positive biopsies. A total of 106 patients underwent FT using high-intensity focused ultrasonography (HIFU), brachytherapy, cryotherapy, or vascular-targeted photodynamic therapy (VTP).

Outcome measurements and statistical analysis

Complications were prospectively recorded and graded according to the Clavien-Dindo scale. Data were prospectively collected and retrospectively analyzed.

Results and limitations

This study included 106 patients, median age 66.5 yr (interquartile range [IQR]): 61-73), who had a prostate hemiablation; 50 patients (47 % ) had cryotherapy, 23 patients (22 % ) had VTP, 21 patients (20 % ) received HIFU, and 12 patients (11 % ) had brachytherapy. The median prostate-specific antigen (PSA) level was 6.1 ng/ml (IQR: 5-8.1), all the patients had a biopsy Gleason score of 6, and the median prostate weight was 43 g (IQR: 33-55). The median International Prostate Symptom Score was 6 (IQR: 3-10), and the median International Index of Erectile Function score was 20 (IQR: 15-23). After treatment, the median PSA at 3, 6, and 12 mo was 3.1 2.9, and 2.7 ng/ml (IQR: 2-5.1, 1.1-4.7, and 1-4.4), respectively. Thirteen percent of the patients experienced treatment-related complications. There were 11 minor medical complications (10 grade 1 complications and 1 grade 2 complication), 2 grade 3 complications, and no grade 4 or higher complications.

Conclusions

FT for a highly selected population with PCa is feasible and had an acceptable morbidity with <2 % major complications.