- 作者：Matthijs F.L. Meijs ; MD ; Pieter A. Doevendans ; MD ; PhD ; Maarten J. Cramer ; MD ; PhD ; Evert-Jan A. Vonken ; MD ; PhD ; Birgitta K. Velthuis ; MD ; PhD ; Yolanda van der Graaf ; MD ; PhD ; Frank L. Visseren ; MD ; PhD ; Willem P.Th.M. Mali ; MD ; PhD ; Michiel L. Bots ; MD ; PhD ; m.l.bots@umcutrecht.nl ; SMART Study group
- 关键词：Cardiac magnetic resonance imaging ; Carotid intima-media thickness ; Left ventricular mass ; Hypertension ; Risk factors
- 刊名：Journal of the American Society of Echocardiography
- 出版年：2009
- 出版时间：May 2009
- 年：2009
- 卷：22
- 期：5
- 页码：499-504
- 全文大小：320 K
lass=""h4"">Background
It is unclear whether the relationship between common carotid intima-media thickness (cCIMT) and left ventricular mass (LVM) is due to shared risk factors for atherosclerosis or for hypertrophy.lass=""h4"">Methods
In 525 hypertensive subjects at high cardiovascular risk, the relation of cCIMT to LVM and established vascular risk factors was studied.
lass=""h4"">Results
CCIMT was positively related to LVM. In a multivariable model including age, gender, height, weight, and LVM, a 1-g increase in LVM related to an increase in cCIMT of 1.6 ¦Ìm (95 % confidence interval, 0.8-2.4). After adjustment for atherosclerotic risk factors, notably previous stroke or transient ischemic attack, peripheral arterial disease, lipid-lowering medication, albuminuria and current smoking, the relation remained unchanged. In contrast, addition of systolic and diastolic blood pressure and hypertension treatment attenuated Beta for the relation between cCIMT and LVM with 19 % to 1.3 ¦Ìm (95 % confidence interval, 0.2-2.2).
lass=""h4"">Conclusion
The relationship between cCIMT and LVM may be due to risk factors for hypertrophy rather than for atherosclerotic factors in a considerable proportion of patients