Associations between the FKBP5 haplotype, exposure to violence and anxiety in females
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- 作者：Johan Isakssona ; b ; johan.isaksson@neuro.uu.se" class="auth_mail" title="E-mail the corresponding author ; Erika Comascoa ; Cecilia Å ; slundc ; Mattias Rehnc ; Catherine Tuvbladd ; e ; Henrik Andershede ; Kent W. Nilssonc
- 关键词：FKBP5 ; Anxiety ; Depression ; Exposure to violence ; Sex differences
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：196-204
- 全文大小：848 K
文摘
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The FK506-binding protein 5 (FKBP5) is an important regulator of the HPA axis.
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Two independent community samples of adolescents and young adults were included.
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The FKBP5 risk haplotype conferred higher anxiety in females in the presence of violence.
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Exposure to violence and female sex were associated with anxiety and depression ratings.