Fetal programming and systemic sclerosis

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• 作者：Gianpaolo Donzelli ; MD ; PhD^a ; ^{gianpaolo.donzelli@unifi.it" class="auth_mail" title="E-mail the corresponding author} ; Giulia Carnesecchi ; MD^c ; Carolina Amador ; MD ; PhD^a ; Mariarosaria di Tommaso ; MD ; PhD^d ; Luca Filippi ; MD^a ; Roberto Caporali ; MD^e ; Veronica Codullo ; MD ; PhD^e ; Valeria Riccieri ; MD^f ; Guido Valesini ; MD^f ; Armando Gabrielli ; MD^g ; Roberta Bagnati ; MD^g ; Kathleen S. McGreevy ; PhD^b ; Salvatore De Masi ; MD^a ; Marco Matucci Cerinic ; MD ; PhD^c
• 关键词：autoimmune disease ; birthweight ; epigenetics ; fetal programming ; scleroderma
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：213
• 期：6
• 页码：839.e1-839.e8
• 全文大小：348 K

文摘

This study investigated whether birthweight is linked to an increased risk of the development of systemic sclerosis.

Study Design

This was a multicenter case-control study with perinatal data that were obtained from 332 cases with systemic sclerosis and 243 control subjects. Birthweight was treated as a dichotomous variable (<2500 g vs ≥2500 g); low birthweight was defined as a weight <2500 g; small for gestational age was defined as birthweight <10th percentile for gestational age adjusted for sex. The relationship between systemic sclerosis and both low birthweight and small for gestational age was expressed with the crude (univariate analysis) and adjusted (multivariate analysis) odds ratio (OR).

Results

Significantly increased ORs were observed in the univariate analysis for low birthweight (OR, 2.59; 95% confidence interval [CI], 1.39–5.05) and small for gestational age (OR, 2.60; 95% CI, 1.34–5.32) subjects. Similarly increased risks were confirmed for both conditions in the multivariate analysis (OR, 3.93; 95% CI, 1.92–8.07; and OR, 2.58; 95% CI, 1.28–5.19), respectively.

Conclusion

Low birthweight and small for gestational age at birth are risk factors for the adult onset of systemic sclerosis.