Development and validation of a fast micro-extraction by packed sorbent UHPLC-PDA method for the simultaneous determination of linezolid and ciprofloxacin in human plasma from patients with hospital-acquired pneumonia

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• 作者：Vincenzo Ferrone^a ; Maura Carlucci^b ; Roberto Cotellese^b ; Paolo Raimondi^b ; Annadomenica Cichella^b ; Lorenzo Di Marco^a ; Giuseppe Carlucci^a ; ^{gcarlucci@unich.it}
• 关键词：Linezolid ; Ciprofloxacin ; Ulifloxacin ; MEPS ; UHPLC-PDA ; Method validation ; Human plasma
• 刊名：Talanta
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：164
• 期：Complete
• 页码：64-68
• 全文大小：416 K
• 卷排序：164

文摘

A novel sampling and clean-up procedure using micro extraction with packed sorbent. UHPLC-PDA method development and validation. First MEPS-UHPLC-PDA method for determination of linezolid and ciprofloxacin in human blood. Therapeutic drug monitoring in patients with hospital acquired pneumonia.