Mechanistic approach in powder blending PAT: Bi-layer mixing and asymptotic end point prediction
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- 作者：Juraj Sibik ; juraj.sibik@roche.com ; Pascal Chalus ; Lene Maurer ; Avinash Murthy ; Siegfried Krimmer
- 关键词：Powder mixing ; Convection ; Blend uniformity ; NIR ; Process analytical technology ; Quality by design
- 刊名：Powder Technology
- 出版年：2017
- 出版时间：15 February 2017
- 年：2017
- 卷：308
- 期：Complete
- 页码：306-317
- 全文大小：2073 K
- 卷排序：308
文摘
A new physical mixing model is derived for a bin blender. The model fits well the acquired NIR real-time blending data. The model defines a quantitative mixing coefficient for each ingredient. The model allows to set a robust and universal blending end point criteria. The methodology is perfectly transferable across production lines and products.