Decreased immune response in alexithymic women: A cross-sectional study

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• 作者：Olivier Guilbaud ; Florence Curt ; Claire Perrin ; Gé ; rard Chaouat ; Sylvie Berthoz ; Corinne Dugré ; -Le Bigre ; Jenny Wallier ; Martine Strebler ; Catherine Touitou ; Philippe Jeammet ; Maurice Corcos
• 关键词：Alexithymia ; Cytokines ; Immunity ; Psychoneuroimmunology
• 刊名：Biomedicine and Pharmacotherapy
• 出版年：2009
• 出版时间：May 2009
• 年：2009
• 卷：63
• 期：4
• 页码：297-304
• 全文大小：193 K

文摘

It has been reported in a few studies that alexithymia is associated with impaired immune response but results are still contradictory. The present study investigates whether alexithymia is associated with lower cell-mediated (Th-1) immune response. Fifty-one healthy 18–27-year-old women were selected from healthy subjects on the basis of high or low cut-off scores on the 20-item Toronto Alexithymia Scale (TAS-20). They were evaluated using standardized psychiatric rating scales notably the Hospital Anxiety Depressive Scale (HAD) and the Mini Neuropsychiatric Interview (MINI). None of the subjects were suffering from psychiatric disorders. Twenty-seven were classified as alexithymics and 24 as non-alexithymics according to the TAS-20. Blood was drawn for lymphocyte subset counts (CD4, CD8), in vitro production of interleukin 1 (IL-1β), IL-2, IL-4, and IL-10 by phytohaemagglutinin stimulated peripheral lymphocytes, and cortisol. Women with alexithymia exhibited decreased interleukin 1β, IL-2 and IL-4 production with reduced ratios of Th1/Th2 (IL-2/IL-10) and of CD4/CD8, as well as reduced CD4 percentages. IL-2 and IL-4 production remained significantly diminished in the alexithymic group, even after adjusting for between-group differences in anxiety and depression levels on the HAD. This study further demonstrates that alexithymic women have altered immune function, with a predominance of depressed cell-mediated immunity and a skewed Th1/Th2 ratio towards Th2 response.