Small molecules modulation of 14-3-3 protein-protein interactions

详细信息    查看全文

• 作者：Mattia Mori ; Giulia Vignaroli ; Maurizio Botta
• 刊名：Drug Discovery Today: Technologies
• 出版年：2013
• 出版时间：December, 2013
• 年：2013
• 卷：10
• 期：4
• 页码：e541-e547
• 全文大小：3272 K

文摘

14-3-3 is a family of highly conserved regulatory proteins which is attracting a significant interest due to its potential role as target for pharmacological intervention against cancer and neurodegenerative disorders. Although modulating protein-protein interactions (PPI) is still conceived as a challenging task in drug discovery, in past few years peptide inhibitors and small molecular modulators of 14-3-3 PPI have been described. Here we examine structural and biological features of 14-3-3 and propose an overview on techniques used for discovering small molecular inhibitors and stabilizers of 14-3-3 PPI.