Proteome database of hepatocellular carcinoma
详细信息 查看全文
- 作者：Liang ; Rosa C.M.Y. ; Neo ; Jason C.H. ; Ling Lo ; Siaw ; San Tan ; Gek ; Keong Seow ; Teck ; Chung ; Maxey C.M.
- 关键词：Reviews ; Proteomics ; Hepatocellular carcinoma
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2002
- 出版时间：May 5, 2002
- 年：2002
- 卷：771
- 期：1-2
- 页码：303-328
- 全文大小：1.58 M
文摘
Hepatocellular carcinoma (HCC or hepatoma) is the most common primary cancer of the liver. Persistent viral infection by the hepatic B or C virus is probably the most important cause of HCC worldwide. It is responsible for approximately one million deaths each year, predominantly in the underdeveloped and developing countries, but its incidence is also on the rise in the developed countries. For most patients suffering from HCC, long-term survival is rare, as they are presented late and are often unsuitable for curative treatment. Thus there is great interest to identify novel HCC diagnostic markers for early detection of the disease, and tumour specific associated proteins as potential therapeutic targets in the treatment of HCC. Proteome analyses of HCC cell lines and liver tumour tissues should facilitate the screening and discovery of these HCC proteins. The creation of a comprehensive HCC proteome database would be an important first step towards achieving this goal. This review presents an update of the two-dimensional electrophoresis proteome database of the cell line, HCC-M, which is also now freely accessible through the World Wide Web at http://proteome.btc.nus.edu.sg/hccm/.