Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities
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- 作者：Angé ; lique Nicolas Messia ; José ; phine Ngo Mbinga ; b ; jpmbing15@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Joseph Thierry Ndongoc ; Maximilienne Ascension Nyegued ; Alembert Tiabou Tchindab ; Flora Ladoh Yemedad ; Michel Fré ; dé ; riche ; Dieudonné ; Emmanuel Pegnyemba ; pegnyemb@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; epegny@uycdc.uninet.cm" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ochnaceae ; Isobiflavonoid ; Structural elucidation ; Antioxidant and antiplasmodial activities
- 刊名：Phytochemistry Letters
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：17
- 期：Complete
- 页码：119-125
- 全文大小：443 K
文摘
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Three new compounds namely 4⿴-methoxylophirone A (1); 4,4⿲-4⿴⿿trimethoxylophirone A (2) and (4E;7Z)-3,8-dicarboxy-1-(O-β-d-glucopyranosyl-(1 ⿿ 6)-O-β-d-glucopyranosyl-2,9-dihydroxyhexeicosa-4,7-diene (3) were isolated from the roots of Ochna schweinfurthiana along with six known compounds.
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Some of the isolated compounds were evaluated for their antiplasmodial activity against the 3D7chloroquine-sensitive strain of Plasmodium falciparum and antioxidant activity was determined.
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Compound 5 showed a prominent radical scavenging (SC50 = 0.17 μM) and Ferric reducing-antioxidant power activity (214.32 μg EAA/mg dw) and 1 showed good in vitro anti-plasmodial activity (IC50 = 08.43 μM).