Optimal elastomeric scaffold leaflet shape for pulmonary heart valve leaflet replacement

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• 作者：Rong Fan^a ; Ahmed S. Bayoumi^b ; Peter Chen^b ; Christopher M. Hobson^c ; William R. Wagner^c ; John E. Mayer Jr.^b ; Michael S. Sacks^a ; ^{msacks35@gmail.com} ; ^{msacks@pitt.edu}
• 关键词：Tissue engineering ; Constitutive modeling ; Finite element ; Leaflet replacement surgery ; Biomechanics
• 刊名：Journal of Biomechanics
• 出版年：2013
• 出版时间：22 February, 2013
• 年：2013
• 卷：46
• 期：4
• 页码：662-669
• 全文大小：1814 K

文摘

Surgical replacement of the pulmonary valve (PV) is a common treatment option for congenital pulmonary valve defects. Engineered tissue approaches to develop novel PV replacements are intrinsically complex, and will require methodical approaches for their development. Single leaflet replacement utilizing an ovine model is an attractive approach in that candidate materials can be evaluated under valve level stresses in blood contact without the confounding effects of a particular valve design. In the present study an approach for optimal leaflet shape design based on finite element (FE) simulation of a mechanically anisotropic, elastomeric scaffold for PV replacement is presented. The scaffold was modeled as an orthotropic hyperelastic material using a generalized Fung-type constitutive model. The optimal shape of the fully loaded PV replacement leaflet was systematically determined by minimizing the difference between the deformed shape obtained from FE simulation and an ex-vivo microCT scan of a native ovine PV leaflet. Effects of material anisotropy, dimensional changes of PV root, and fiber orientation on the resulting leaflet deformation were investigated. In-situ validation demonstrated that the approach could guide the design of the leaflet shape for PV replacement surgery.