Expression of human antibodies in eukaryotic micro-algae

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• 作者：Mayfield ; Stephen P. ; Franklin ; Scott E.
• 关键词：Algae ; Chlamydomonas reinhardtii ; IgA ; Human monoclonal antibodies ; Single chain antibodies
• 刊名：Vaccine
• 出版年：2005
• 出版时间：March 7, 2005
• 年：2005
• 卷：23
• 期：15
• 页码：1828-1832
• 全文大小：167 K

文摘

Protein based therapeutics have enjoyed great success over the past decade. Unfortunately, with this clinical success comes a heavy price tag, owing to the inherently high costs of capitalization and production using mammalian cell fermentation. To address this problem, we have begun developing a system for the expression of recombinant proteins in the unicellular eukaryotic green algae, Chlamydomonas reinhardtii, leading to the production of human IgA single chain antibodies.