Role of anti-interferon antibodies in breakthrough occurrence during alpha 2a and 2b therapy in patients with chronic hepatitis C
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- 作者：Leroy ; Vincent ; Baud ; Marilyne ; de Traversay ; Caroline ; Maynard-Muet ; Marianne ; Lebon ; Pierre ; et. al.
- 关键词：Anti-interferon antibodies ; Breakthrough ; Chronic hepatitis C ; Recombinant alpha interferon.
- 刊名：Journal of Hepatology
- 出版年：1998
- 出版时间：March, 1998
- 年：1998
- 卷：28
- 期：3
- 页码：375-381
- 全文大小：114 K
文摘
Background/Aims: Alpha interferon induces aminotransferase normalization in about 50 % of patients with chronic viral hepatitis C. However, some patients who initially respond experience a relapse during the treatment period (breakthrough phenomenon). The aim of this study was to evaluate the prevalence of breakthrough and its relationship with the emergence of neutralizing anti-interferon antibodies.