A phenyldilactone, bisnorsesquiterpene, and cytotoxic phenolics from Maytenus senegalensis leaves

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• 作者：Festus Basden Chiedu Okoye^a ; ^b ; ^{fb.okoye@unizik.edu.ng" class="auth_mail} ; ^{basdenc@yahoo.com" class="auth_mail} ; Abdessamad Debbab^a ; Victor Wray^c ; Charles Okechukwu Esimone^d ; Patience Ogoamaka Osadebe^b ; ^e ; Peter Proksch^a ; ^{proksch@uni-duesseldorf.de" class="auth_mail}
• 关键词：Maytenus senegalensis ; Celastraceae ; Cytotoxicity ; Lactones ; Bisnorsesquiterpenes ; Phenolics
• 刊名：Tetrahedron Letters
• 出版年：9 July 2014
• 年：2014
• 卷：55
• 期：28
• 页码：3756-3760
• 全文大小：475 K

文摘

Maytenus senegalensis Lam. (Celastraceae) leaves are traditionally used in West Africa for the management of cancer and other disorders associated with inflammation. In this study, bioactivity-guided fractionation of the methanol leaf extract of Maytenus senegalensis led to the isolation of 11 compounds, including the new phenyldilactone, maysedilactone (1). All isolated compounds were tested for cytotoxicity against mouse lymphoma cell line (L5178Y). Only (−) epigallocathechin showed high cytotoxicity and completely inhibited cell growth at the investigated dose of 10 渭g/mL. This result supports the claimed efficacy of Maytenus senegalensis leaf extract in ethnomedicinal treatment of cancer.