Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae

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• 作者：Alexandra R. Willis¹ ; Christopher Moore² ; Maria Mazon-Moya¹ ; Sina Krokowski¹ ; Carey Lambert² ; Robert Till² ; Serge Mostowy¹ ; ³ ; ^{s.mostowy@imperial.ac.uk} ; R. Elizabeth Sockett² ; ^{liz.sockett@nottingham.ac.uk}
• 关键词：antibacterial ; antibiotic ; Bdellovibrio ; innate immunity ; predation ; Shigella ; zebrafish
• 刊名：Current Biology
• 出版年：2016
• 出版时间：19 December 2016
• 年：2016
• 卷：26
• 期：24
• 页码：3343-3351
• 全文大小：2898 K
• 卷排序：26

文摘

Injected predatory Bdellovibrio bacteria persist non-pathogenically in zebrafish Bdellovibrio injection promotes Shigella killing and increases zebrafish survival Bdellovibrio are eventually cleared by the zebrafish immune system Antibacterial therapy is achieved via the host immune system working with Bdellovibrio