Glassy carbon electrodes deliver unpredictable reduction potentials for platinum(IV) antitumor prodrugs

详细信息    查看全文

• 作者：Meghan C. McCormick^a ; Franklin A. Schultz^b ; Mu-Hyun Baik^c ; ^d ; ^{mbaik2805@kaist.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Electrochemistry ; Non-Nernstian redox behavior ; Electrode ; Pt(IV) prodrugs ; Cisplatin
• 刊名：Polyhedron
• 出版年：2016
• 出版时间：8 January 2016
• 年：2016
• 卷：103
• 期：part_PA
• 页码：28-34
• 全文大小：1344 K

文摘

Reductive activation of six-coordinate Pt(IV) complexes to afford square-planar Pt(II) complexes has exhibited surprisingly divergent and unpredictable cathodic peak potentials during cyclic voltammetry (CV) measurements under widely employed experimental conditions. A systematic, detailed investigation reveals that glassy carbon (GC) electrodes are responsible for this erratic behavior. More reproducible CVs are obtained with platinum metal electrodes, which display cathodic responses at much more positive potentials. The unreliable and negatively shifted peak potentials observed at GC are attributed to a non-uniform oxide layer that is formed on the electrode surface causing slow electron transfer. A simple procedure of repetitive scanning to reducing potentials is found to be effective for cleaning and activating the GC surface, such that it exhibits the more consistent and accurate peak potential responses seen with a Pt electrode.