Asymmetric Morita-Baylis-Hillman reaction catalyzed by pepsin
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- 作者：Jing-Wen Xuea ; Jian Songa ; Ian C.K. Manionb ; Yan-Hong Hea ; heyh@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhi Guana ; guanzhi@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Porcine pepsin ; Asymmetric MBH reaction ; Biocatalyst ; Enzyme catalytic promiscuity
- 刊名：Journal of Molecular Catalysis B: Enzymatic
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：62-69
- 全文大小：981 K
文摘
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Pepsin-catalyzed Morita–Baylis–Hillman (MBH) reaction was described.
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15 examples of MBH products were obtained by this reaction.
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The novel reaction also expands the field of organic synthesis.
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This work promotes the development of enzyme catalytic promiscuity.