Sexually Dimorphic Differentiation of a C. elegans Hub Neuron Is Cell Autonomously Controlled by a Conserved Transcription Factor

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• 作者：Esther Serrano-Saiz¹ ; ^{es2754@columbia.edu} ; Meital Oren-Suissa¹ ; Emily A. Bayer¹ ; Oliver Hobert¹ ; ² ; ^{or38@columbia.edu}
• 刊名：Current Biology
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：27
• 期：2
• 页码：199-209
• 全文大小：3178 K
• 卷排序：27

文摘

In C. elegans males, the sex-shared PHC neurons differentiate into hub neurons Sex-specific differentiation allocates distinct, sex-specific functions to PHC Hub neuron differentiation involves transcriptional scaling of synaptic machinery The DMD-3 transcription factor cell-autonomously controls hub neuron specification