Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1

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• 作者：Junya Suzuki^a ; Wataru Nakajima^a ; Hidenori Suzuki^b ; Yumi Asano^a ; Nobuyuki Tanaka^a ; ^{nobuta@nms.ac.jp}
• 关键词：Chaperone-mediated autophagy ; Lung cancer ; MCL1 ; Ubiquitination ; Apoptosis ; Cancer chemotherapy
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1334-1340
• 全文大小：1995 K
• 卷排序：482

文摘

Lysosomal proteolysis attenuates crizotinib-induced apoptosis in NSCSC cells. Crizotinib-induced apoptosis is enhanced by inhibition of lysosomal proteolysis. MCL1 degradation is suppressed by chaperone-mediated autophagy (CMA). CMA-mediated stabilization of MCL1 was observed in several NSCLC cell lines. CMA inhibition and ABT-263 efficiently induces apoptosis in NSCLC cells.