Identification and pharmacological analyses of eight naturally occurring caprine melanocortin-1 receptor mutations in three different goat breeds
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- 作者：Qi Xionga ; b ; 1 ; Jin Chaib ; c ; 1 ; Mingxin Chena ; Ya-Xiong Taob ; taoyaxi@auburn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：EL ; extracellular loop ; ERK1/2 ; extracellular signal-regulated kinases 1 and 2 ; gMC1R ; goat MC1R ; GPCR ; G protein-coupled receptor ; IL ; intracellular loop ; LD ; linkage disequilibrium ; MC1R ; melanocortin-1 receptor ; MC3R ; melanocortin-3 receptor ; MC4R ; melanocortin-4 receptor ; MITF ; microphthalmia-associated transcription factor ; MSH ; melanocyte stimulating hormone ; NDP-MSH ; [Nle4 ; ; D-Phe7]-α-melanocyte stimulating hormone ; pERK1/2 ; phosphorylated ERK1/2 ; TM ; transmembrane ; WT ; wild type
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：235
- 期：Complete
- 页码：1-10
- 全文大小：2111 K
文摘
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Eight naturally occurring caprine melanocortin-1 receptor (MC1R) mutations in three different goat breeds were identified.
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Some cMC1R mutants were defective in ligand binding and some mutants were defective in basal signaling.
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Some cMC1R mutants exhibited biased signaling in cAMP and ERK1/2 signaling pathways.