Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer
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- 作者：Baiyu Yanga ; b ; 1 ; Aaron P. Thriftc ; 1 ; Jane C. Figueiredod ; Mark A. Jenkinse ; Fredrick R. Schumacherd ; David V. Contid ; Yi Linf ; Aung Ko Wine ; Paul J. Limburgg ; Sonja I. Berndth ; Hermann Brenneri ; j ; k ; Andrew T. Chanl ; m ; Jenny Chang-Clauden ; Michael Hoffmeisteri ; Thomas J. Hudsono ; p ; q ; Loï ; c Le Marchandr ; Polly A. Newcombf ; s ; Martha L. Slatteryt ; Emily Whitef ; s ; Ulrike Petersf ; s ; Graham Caseyd ; Peter T. Campbella ; Peter.Campbell@cancer.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMI ; body mass index ; CCFR ; Colon Cancer Family Registry ; CI ; confidence interval ; FTO ; fat-mass and obesity-associated ; GECCO ; Genetics and Epidemiology of Colorectal Cancer Consortium ; GWAS ; genome-wide association study ; MAF ; minor allele frequency ; MC4R ; melanocortin-4 receptor ; OR ; odds ratio ; PCA ; principal component of genetic ancestry ; SNP ; single nucleotide polymorphism
- 刊名：Cancer Epidemiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：1-4
- 全文大小：261 K
文摘
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r0005">Variants in or near FTO and MC4R genes have been associated with obesity, a convincing risk factor for colorectal cancer.
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r0010">We found no associations of individual variants in or near FTO and MC4R with risk of colorectal cancer.
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r0015">This paper is the largest and most comprehensive evaluation of obesity-related genes FTO and MC4R with colorectal cancer risk.