Programmatic implementation of blastocyst transfer in a university-based in vitro fertilization clinic: maximizing pregnancy rates and minimizing triplet rates

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• 作者：James A. Grifo ; Eric Flisser ; Alexis Adler ; Caroline McCaffrey ; Lewis C. Krey ; Frederick Licciardi ; Nicole Noyes ; Lisa M. Kump ; Alan S. Berkeley
• 刊名：Fertility and Sterility
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：88
• 期：2
• 页码：294-300
• 全文大小：106 K

文摘

To assess whether the use of extended embryo culture can reduce the incidence of high-order multiple gestations, a retrospective analysis of 7,418 fresh ETs performed in a university-based IVF clinic from 1997–2003 was conducted, comparing program results before and after institution of a protocol to select patients for extended culture of in vitro fertilized embryos. The incidence of triplet pregnancies was significantly reduced in patients at highest risk for high-order multiple gestations, i.e., those at <35 years of age (16.8 % versus 6.8 % ), those at 35–37 years of age (13.0 % versus 5.6 % ), and recipients of donated oocytes (11.2 % versus 4.5 % ).