- 作者：Mai-Anh T. Vu ; Heidi W. Thermenos ; Douglas P. Terry ; David J. Wolfe ; Martina M. Voglmaier ; Margaret A. Niznikiewicz ; Robert W. McCarley ; Larry J. Seidman ; Ch ; lee C. Dickey
- 关键词：Schizotypal personality disorder ; Working memory ; Functional magnetic resonance imaging (fMRI) ; 2-Back task ; Cognition ; Schizophrenia
- 刊名：Schizophrenia Research
- 出版年：December, 2013
- 年：2013
- 卷：151
- 期：1-3
- 页码：113-123
- 全文大小：1572 K
Background
Schizotypal personality disorder (SPD) is considered a schizophrenia spectrum disorder, sharing with schizophrenia cognitive, neuropsychological, epidemiological, and biological characteristics. Working memory may be one area of shared deficit, although to date, this is only the second study to investigate working memory in SPD using fMRI.Methods
In a block-design fMRI study, fifteen antipsychotic-na茂ve SPD and sixteen healthy control subjects performed blocks of a 2back visual working memory task and 0back continuous performance task while undergoing whole-brain fMRI at 3 T. Whole-brain analyses were performed for the 0back > rest (fixation baseline) and the 2back > 0back contrasts (isolating the working memory component from the visual perception and attention component). Parameter estimates were extracted to determine whether observed differences were due to task-induced activation and/or deactivation.
Results
Activation differences emerged between the two groups, without differences in task performance. In the 0back task, SPD showed decreased task-induced activation of the left postcentral gyrus. In the 2back > 0back contrast, HC showed greater task-induced activation of the left posterior cingulate gyrus, superior temporal gyrus, insula, and middle frontal gyrus. These differences were due to SPD subjects' decreased task-induced activation in the left posterior cingulate gyrus, and task-induced deactivation in the remaining regions.
Conclusions
These findings suggest that compared to HC subjects, individuals with SPD may achieve comparable working memory performance. However, differences emerge at the level of functional neural activation, attributable to different task-induced activation and deactivation patterns. Such differential recruitment of neural resources may be beneficial, contributing to SPD subjects' ability to perform these tasks comparably to HC subjects.