Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens
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- 作者：Istvan Botos1 ; 5 ; Nadim Majdalani2 ; 5 ; Stephen J. Mayclin1 ; 5 ; Jennifer Gehret McCarthy1 ; 5 ; Karl Lundquist3 ; Damian Wojtowicz4 ; Travis J. Barnard1 ; James C. Gumbart3 ; Susan K. Buchanan1 ; skbuchan@helix.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：7 June 2016
- 年：2016
- 卷：24
- 期：6
- 页码：965-976
- 全文大小：5584 K
文摘
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LptD forms a 26-strand bilobed β barrel with LptE inserted inside
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The N-terminal domain of KpLptDE rotates 21° compared with SfLptDE
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Pro residues in β1 and β2 play critical roles in the lateral opening of the barrel
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All LptDE structures have a negatively charged lumen that may aid LPS insertion