- 作者：Allison C. Ross ; Mary Ann O’ ; Riordan ; Norma Storer ; Vikram Dogra ; Grace A. McComsey
- 关键词：HIV ; Cardiovascular disease ; Children ; Inflammation ; Hyperlipidemia
- 刊名：Atherosclerosis
- 出版年：2010
- 出版时间：August 2010
- 年：2010
- 卷：211
- 期：2
- 页码：492-498
- 全文大小：132 K
ObjectivesHIV+ patients are at increased risk of cardiovascular disease (CVD). Inflammation plays a role in adults, but has not yet been assessed in HIV+ children. We compared proinflammatory cytokines and adhesion molecules in HIV+ children versus healthy controls, and assessed their relationship to carotid intima-media thickness (IMT).Methods
Evaluations were performed on 27 HIV+ children and 30 HIV-healthy controls (2-21 years) who were prospectively enrolled in our pediatric cohort. Measurements included internal carotid artery (ICA) and common carotid artery (CCA) IMT, fasting lipids, insulin, proinflammatory markers (TNF-α, soluble TNF receptors (sTNFR-I, -II), IL-6, high sensitivity C-reactive protein (hsCRP), myeloperoxidase (MPO)), and adhesion molecules (soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1 (sVCAM-1), von Willebrand factor).
Results
Among HIV+, mean age was 11 years, 33 % males, 70 % black. 96 % acquired HIV vertically; median CD4 count (CD4 % ) was 1058 (35 % ) cells/ml; 96 % were on antiretroviral therapy (ART); 70 % had HIV-1 RNA <50 copies/ml. Groups were similar in age, race, sex, BMI, proinflammatory cytokines, adhesion markers, and carotid IMT except for hsCRP which was higher in HIV+ (P < 0.001). In multiple regression analyses, hCRP, age, and female sex were positively associated with IMT. ART duration and sTNFR-II were positively associated with sVCAM-1.
Conclusions
This study shows increased hsCRP in HIV+ children compared to healthy controls. As seen in adults, hCRP was associated with carotid IMT, which support a role for inflammation in CVD risk of HIV+ children.