Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery

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• 作者：Nia M. Harris^a ; Rodney Ritzel^a ; Nikolas Mancini^a ; Yuhang Jiang^d ; Xiang Yi^d ; Devika S. Manickam^d ; ¹ ; William A. Banks^b ; ^c ; Alexander V. Kabanov^d ; Louise D. McCullough^a ; ^e ; Rajkumar Verma^a ; ^{raverma@uchc.edu} ; ^{rajsanto1979@gmail.com}
• 关键词：Stroke ; Neuroprotection ; Neuro-restorative ; BDNF ; Depressive behavior
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：150-151
• 期：Complete
• 页码：48-56
• 全文大小：1363 K
• 卷排序：150

文摘

Nano-formulation of BDNF is both neuro-protective and neuro-restorative. Early treatment with nano-BDNF reduces infarct after stroke. Delayed treatment ameliorates depressive behavior and memory loss.