From microbiology to cell biology: when an intracellular bacterium becomes part of its host cell

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• 作者：John P McCutcheon p>john.mccutcheon@umontana.edu" class="auth_mail" title="E-mail the corresponding authorp>
• 刊名：Current Opinion in Cell Biology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：41
• 期：Complete
• 页码：132-136
• 全文大小：482 K

文摘

Mitochondria and chloroplasts are now called organelles, but they used to be bacteria. As they transitioned from endosymbionts to organelles, they became more and more integrated into the biochemistry and cell biology of their hosts. Work over the last 15 years has shown that other symbioses show striking similarities to mitochondria and chloroplasts. In particular, many sap-feeding insects house intracellular bacteria that have genomes that overlap mitochondria and chloroplasts in terms of size and coding capacity. The massive levels of gene loss in some of these bacteria suggest that they, too, are becoming highly integrated with their host cells. Understanding these bacteria will require inspiration from eukaryotic cell biology, because a traditional microbiological framework is insufficient for understanding how they work.