- 作者：Jessica A. Walsh ; Molly McFadden ; Jamie Woodcock ; Daniel O. Clegg ; Philip Helliwell ; Erica Dommasch ; Joel M. Gelf ; Gerald G. Krueger ; Kristina Callis Duffin
- 关键词：disease activity instrument ; Physician Global Assessment ; product of Physician Global Assessment and Body Surface Area ; psoriasis ; Psoriasis Area and Severity Index ; severity measurement
- 刊名：Journal of the American Academy of Dermatology
- 出版年：December, 2013
- 年：2013
- 卷：69
- 期：6
- 页码：931-937
- 全文大小：117 K
Background
The Psoriasis Area and Severity Index (PASI) is considered the gold standard assessment tool for psoriasis severity, but PASI is limited by its complexity and insensitivity in people with mild psoriasis.Objective
We sought to evaluate the product of a Physician Global Assessment (PGA) and Body Surface Area (BSA) (PGAxBSA) as an alternative to PASI.
Methods
Psoriasis severity was evaluated at 6-month intervals in participants of the Utah Psoriasis Initiative registry. Correlation coefficients were used to compare PGAxBSA with PASI and the Simplified PASI (SPASI).
Results
Between August 2008 and November 2010, 435 assessments were completed in 226 participants. The median PASI score was 3.2 (interquartile range 1.8-5.4) and the median BSA was 3.0% (interquartile range 1.0%-5.0%). PGAxBSA had higher correlations with PASI than SPASI (0.87 vs 0.76, P聽<聽.001). PGAxBSA also had higher correlations with a Global Patient Assessment of psoriasis severity (0.65) than both PASI (0.59, P聽<聽.001) and SPASI (0.51, P聽<聽.001).
Limitations
The use of PGAxBSA for measuring severe psoriasis and response to therapy is unclear, because most participants had mild to moderate psoriasis and data were not collected at predefined intervals in relation to therapy initiation. Interrater reliability was not assessed.
Conclusions
PGAxBSA is a simple and sensitive instrument for measuring psoriasis severity.