Posttraumatic seizures and epilepsy in adult rats after controlled cortical impact
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- 作者：Kevin M. Kellya ; b ; c ; d ; kelly@wpahs.org" class="auth_mail" title="E-mail the corresponding author ; Eric R. Millera ; emiller@wpahs.org" class="auth_mail" title="E-mail the corresponding author ; Eka Lepsveridzee ; eka_lepsveridze@iliauni.edu.ge" class="auth_mail" title="E-mail the corresponding author ; Elena A. Kharlamova ; b ; c ; Zakaria Mchedlishvilia ; b ; c ; zmchedlishvili@sentientmedical.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TBI ; traumatic brain injury ; PTE ; posttraumatic epilepsy ; CCI ; controlled cortical impact ; FPI ; fluid percussion injury ; POD ; postoperative day ; SWD ; spike-wave discharges
- 刊名：Epilepsy Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：117
- 期：Complete
- 页码：104-116
- 全文大小：5236 K
文摘
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Convulsive seizures occurred in 12.3% of animals during the week following CCI.
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Epileptic seizures were recorded in 20.3% of animals following CCI.
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CCI caused severe brain loss and cavitation of the ipsilateral cerebral hemisphere.
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All Timm-stained CCI-injured brains demonstrated ipsilateral mossy fiber sprouting.
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CCI of adult rats can be used to study epileptogenesis and posttraumatic epilepsy.