Single-Cell Resolution of Temporal Gene Expression during Heart Development
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- 作者：Daniel M. DeLaughter1 ; 9 ; Alexander G. Bick1 ; 9 ; Hiroko Wakimoto1 ; David McKean1 ; Joshua M. Gorham1 ; Irfan S. Kathiriya2 ; 3 ; John T. Hinson4 ; Jason Homsy1 ; Jesse Gray1 ; William Pu5 ; 6 ; Benoit G. Bruneau2 ; 7 ; J.G. Seidman1 ; Christine E. Seidman1 ; 8 ; 10 ; cseidman@genetics.med.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：single cell ; RNA-seq ; heart ; cardiogenesis ; cardiomyocyte maturation ; Nkx2.5 ; ECM ; ventricle ; atria
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：39
- 期：4
- 页码：480-490
- 全文大小：2783 K
文摘
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Single-cell RNA-seq data characterizing >1,200 murine cells from E9.5–P21 hearts
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Dynamic spatiotemporal gene expression defines distinct cardiomyocyte populations
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Human/mouse stem-cell-derived cardiomyocytes are developmentally immature
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Nkx2.5+/− mice have lineage-specific maturation defects in cardiac cells