Oxidative stress in the development, maintenance and resolution of paclitaxel-induced painful neuropathy
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- 作者：Natalie A. Duggett ; Lisa A. Griffiths ; Olivia E. McKenna ; Vittorio de Santis ; Nutcha Yongsanguanchai ; Esther B. Mokori ; Sarah J.L. Flatters ; sarah.flatters@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author ;
- 关键词：BSA ; bovine serum albumin ; CGRP ; calcitonin gene-related peptide ; DAPI ; 4' ; 6-diamidino-2-phenylindole ; DMSO ; dimethyl sulfoxide ; DRG ; dorsal root ganglia ; EDTA ; ethylenediaminetetraacetic acid ; FBS ; foetal bovine serum ; FITC ; fluorescein isothiocyanate ; GFAP ; glial fibrillary acidic protein ; GPx ; glutathione peroxidase ; IB4 ; isolectin-B4 ; MEM ; minimum essential media ; NGS ; normal goat serum ; PBS ; phosphate-buffered saline ; PFA ; paraformaldehyde ; ROS ; reactive oxygen species ; SOD ; superoxide dism
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：333
- 期：Complete
- 页码：13-26
- 全文大小：2355 K
文摘
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ROS levels assessed in peripheral and central sensory neurons following paclitaxel.
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Increased ROS levels seen in non-peptidergic neurons prior to paclitaxel-induced pain.
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Elevated ROS levels in spinal neurons, but not microglia/astrocytes, after paclitaxel.
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Assayed activity of main antioxidant enzymes during paclitaxel-evoked pain timecourse.
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Inadequate antioxidant response suggests elevated ROS sustains paclitaxel-evoked pain.