White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure

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• 作者：Christine Fennema-Notestine ; PhD^a ; ^b ; ^{fennema@ucsd.edu} ; Linda K. McEvoy ; PhD^b ; Randy Notestine ; MS^a ; Matthew S. Panizzon ; PhD^a ; Wai-Ying Wendy Yau^c ; Carol E. Franz ; PhD^a ; Michael J. Lyons ; PhD^d ; Lisa T. Eyler ; PhD^a ; Michael C. Neale ; PhD^e ; Hong Xian ; PhD^f ; Ruth E. McKenzie ; PhD^d ; William S. Kremen ; PhD^a ; ^g
• 关键词：White matter ; MRI ; Brain ; Hypertension ; Blood pressure ; Heritability
• 刊名：NeuroImage: Clinical
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：737-745
• 全文大小：1044 K
• 卷排序：12

文摘

White matter abnormalities were highly heritable and associated with hypertension. Only some genetic influences were shared with systolic blood pressure. There is evidence for unique environmental influences unrelated to hypertension. Poorly controlled hypertension was associated with more abnormal white matter. Abnormal white matter may reflect currently active cerebrovascular effects.