Dietary Guideline Adherence Index and Kidney Measures in the Framingham Heart Study

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• 作者：Jiantao Ma ; PhD¹ ; Paul F. Jacques ; DSc² ; Shih-Jen Hwang ; PhD¹ ; Lisa M. Troy ; PhD³ ; Nicola M. McKeown ; PhD² ; Audrey Y. Chu ; PhD¹ ; Caroline S. Fox ; MD¹ ; ^{foxca@nhlbi.nih.gov" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dietary Guidelines for Americans Adherence Index (DGAI) ; meat and legumes ; dairy products ; estimated glomerular filtration rate (eGFR) ; incident low eGFR ; rapid eGFR decline ; renal function ; kidney disease progression ; modifiable risk factor ; diet ; Framingham Heart Study Offspring Cohort ; albuminuria ; urinary albumin-creatinine ratio (UACR)
• 刊名：American Journal of Kidney Diseases
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：68
• 期：5
• 页码：703-715
• 全文大小：2729 K

文摘

No observational studies have directly considered dietary guidelines when examining the prospective association between dietary intake and kidney measures.

Study Design

Prospective cohort study.

Setting & Participants

We examined participants who attended examinations 7 (1998-2001) and 8 (2005-2008) in the Framingham Offspring Cohort.

Predictors

Individual components of Dietary Guidelines for Americans Adherence Index (DGAI) that reflect adherence to key dietary recommendations based on the 2005 guideline.

Outcomes & Measures

The primary outcome was incident low estimated glomerular filtration rate (eGFR) at follow-up after exclusion of prevalent low eGFR at baseline. Low eGFR was defined as serum creatinine−based eGFR < 60 mL/min/1.73 m².

Results

Among 1,822 participants (mean age, 59.4 years; 54.6% women), 181 incident cases of low eGFR were identified. After adjustment for potential confounders, compared to optimal adherence to meat and legume recommendations, low adherence was associated with higher odds of incident low eGFR (P for trend = 0.01); ORs in the lowest and intermediate adherence categories were 2.98 (95% CI, 1.13-7.92) and 1.65 (95% CI, 1.02-2.66), respectively. Low adherence to dairy product recommendations was also associated with higher odds of incident low eGFR compared to optimal adherence (P for trend = 0.03); ORs in the lowest and intermediate adherence categories were 1.98 (95% CI, 1.03-3.82) and 1.59 (95% CI, 0.81-3.11), respectively. In addition, low adherence to meat and legume recommendations was associated with rapid eGFR decline (P for trend = 0.01), and low adherence to dairy product recommendations was associated with rapid eGFR decline (P for trend = 0.01) and incident albuminuria (P for trend = 0.03).

Limitations

The DGAI was developed based on the 2005 Dietary Guidelines for Americans.

Conclusions

Better adherence to dietary recommendations for both meat and legumes and dairy products was associated with lower risk for developing adverse kidney measures.