A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior
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- 作者：Ryan J. McLaughlina ; ryan.mclaughlin@mail.mcgill.ca" class="auth_mail ; ryanmc@psych.ubc.ca" class="auth_mail ; Matthew N. Hillb ; c ; Boris B. Gorzalkad
- 关键词：Endocannabinoid system ; Prefrontal cortex ; Stress ; Emotional behavior
- 刊名：Neuroscience and Biobehavioral Reviews
- 出版年：May 2014
- 年：2014
- 卷：42
- 期：Complete
- 页码：116-131
- 全文大小：875 K
文摘
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The PFC regulates feedback inhibition of the stress response and emotional behavior.
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Local endocannabinoid signaling fine-tunes the PFC response to aversive stimuli.
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Endocannabinoids cooperate with glucocorticoids to modulate PFC pyramidal output.
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Local PFC CB1 receptor activation promotes antidepressant and anxiolytic responses.
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Chronic stress compromises tonic endocannabinoid signaling in the PFC.