In vivo tissue sampling using solid-phase microextraction for non-lethal exposome-wide association study of CYP1A1 induction in Catostomus commersonii
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- 作者：Bessonneau Vincenta ; Ings Jenniferb ; McMaster Markb ; Smith Richardc ; Bragg Leslied ; Servos Markd ; Pawliszyn Janusza ; janusz@uwaterloo.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：In vivo solid-phase microextraction ; Exposome ; Tissue sampling ; CYP1A1 ; Aquatic ecosystem health
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：216-223
- 全文大小：1529 K
文摘
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In vivo SPME tissue sampling offers non-lethal analysis of fish exposome.
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In vivo SPME provides extraction of short-lived and unstable metabolites.
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14 fish tissue metabolites were found as associated with CYP1A1 induction.
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Altered metabolites were involved in 12 metabolic pathways.
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Cases fish presented high inter-individual variability in levels of environmental toxicants.