Pattern of circulation of MCMV mimicking natural infection upon oronasal inoculation
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- 作者：Shunchuan Zhang1 ; Jun Xiang1 ; Lowiese M.B. Desmarets ; Hans J. Nauwynck ; hans.nauwynck@ugent.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：MCMV ; Pathogenesis ; Oronasal inoculation ; Virus dissemination ; Non-productive infection
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 April 2016
- 年：2016
- 卷：215
- 期：Complete
- 页码：114-120
- 全文大小：1402 K
文摘
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Nasal mucosa and NALT are portals of entry for MCMV upon oronasal inoculation.
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Afterwards, MCMV spreads to submandibular lymph nodes (LN) and deep cervical LN, subsequently into spleen possibly via lymph and blood circulation.
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Next, a subsequent cell-associated viremia generated at 7 dpi carries virus to distal organs such as submandibular glands (HaNa1 & Smith), liver and kidneys (Smith).
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The spleen is hypothesized as a transfer hub for regulating viremia and virus dissemination.