Increased Monday Incidence of Life Threatening Ventricular Arrhythmias: Experience with a Third Generation Implantable Defibrillator
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- 作者：Robert W. Peters ; Steve McQuillan ; Susan A. Kaye ; Michael R. Gold
- 刊名：Journal of the American College of Cardiology
- 出版年：1995
- 出版时间：February 1995
- 年：1995
- 卷：25
- 期：2, Supplement 1
- 页码：188A
- 全文大小：112 K
文摘
Examination of the timing of cardiac events provides important pathophysiologic information. We examined the septadian (day of the week) frequency of 5270 episodes of life threatening spontaneous ventricular arrhythmias (prospectively defined as cycle length < 280 ms) in 683 pts with the Ventak PRx, a 3rd generation defibrillator that provides event chronology.
Chi-square goodness of fit analysis revealed nonuniform distribution (p < 0.001) with a major peak on Monday, a secondary peak in late-week and a prominent weekend nadir. This pattern was independent of age, gender, use of antiarrhythmic drugs, ejection fraction, congestive heart failure or type of heart disease (p's > 0.05). We conclude that potentially lethal ventricular arrhythmias are not random events but occur in a daily pattern suggesting a relationship to the beginning and end of the work week. This information may be useful in devising strategies to prevent sudden cardiac death.