Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the wistar rat
详细信息 查看全文
- 作者：O'Loinsigh ; Eamond D. ; Boland ; Gerard ; Kelly ; John P. ; O'Boyle ; Kathy M.
- 关键词：behaviour ; dopamine ; hyperthermia ; [3H]monoamine release ; MDA ; MDBA ; MDEA ; MDMA ; neurotoxicity ; [3H]paroxetine ; serotonin ; dopamine (DA) ; high performance liquid chromatography (HPLC) ; 5-hydroxyindoleacetic acid (5-HIAA) ; monoamine o
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2001
- 出版时间：April, 2001
- 年：2001
- 卷：25
- 期：3
- 页码：621-638
- 全文大小：820 K
文摘
The ability of N-ethyl (MDEA) and N-butyl (MDBA) analogues of 3,4-methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) to induce acute behavioural changes and increases in body temperature, and to cause serotonergic neurotoxicity, was assessed in young adult male Wistar rats. The in vitro ability of MDMA analogues to evoke presynaptic monoamine release from crude rat forebrain synaptosomal preparations pre-labelled with [3H]5-HT or [3H]DA was also measured.