A decorin-deficient matrix affects skin chondroitin/dermatan sulfate levels and keratinocyte function
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- 作者：Katerina Nikolovskaa ; 1 ; Jana K. Renkea ; 1 ; Oliver Jungmanna ; Kay Grobea ; Renato V. Iozzob ; Alina D. Zamfirc ; Daniela G. Seidlera ; dgseidle@uni-muenster.de" class="auth_mail
- 关键词：SLRP ; small leucine-rich proteoglycan ; Dcn&minus ; /&minus ; decorin-null mouse ; GAG ; glycosaminoglycan ; DS ; dermatan sulfate ; CS ; chondroitin sulfate ; Dcn ; mouse decorin gene ; Fgf ; fibroblast growth factor ; ECM ; extracellular matrix ; EDS ; Ehlers&ndash ; Danlos syndrome ; Dse1&minus ; /&minus ; dermatan sulfate epimerase 1-null mice
- 刊名：Matrix Biology
- 出版年：April 2014
- 年：2014
- 卷：35
- 期：Complete
- 页码：91-102
- 全文大小：1177 K
文摘
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The CS/DS content of Dcn−/− skin is increased but less sulfated compared to wild-type.
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Dcn−/− CS/DS displayed a reduced Fgf7 and Fgf2 binding capacity.
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Dcn−/− CS/DS induced keratinocyte proliferation in contrast to wild-type CS/DS.
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In a co-culture system Dcn−/− CS/DS delayed keratinocyte differentiation.