Advances in the molecular dynamics flexible fitting method for cryo-EM modeling
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- 作者：Ryan McGreevya ; Ivan Teob ; Abhishek Singharoya ; Klaus Schultena ; b ; kschulte@ks.uiuc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cryo-electron microscopy ; Molecular dynamics
- 刊名：Methods
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：50-60
- 全文大小：1810 K
文摘
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Cryo-EM is an important tool for structure determination of biomolecular complexes.
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Hybrid computational methods combine data from cryo-EM and X-ray crystallography.
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MDFF is a highly adaptable method for obtaining atomic structures from cryo-EM data.
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New MDFF features developed to overcome challenges faced in molecular modeling.