- 作者：Vincent Hendriks ; Evelien van der Schee ; Peter Blanken
- 关键词：Adolescents ; Cannabis use disorder ; Multidimensional family therapy ; Cognitive behavioral therapy ; Patient-treatment matching
- 刊名：Drug and Alcohol Dependence
- 出版年：2012
- 出版时间：1 September, 2012
- 年：2012
- 卷：125
- 期：1-2
- 页码：119-126
- 全文大小：301 K
Background
In a recent randomized controlled trial (), multidimensional family therapy (MDFT) and cognitive behavioral therapy (CBT) were equally effective in reducing cannabis use in adolescents (13-18 years old) with a cannabis use disorder (n = 109). In a secondary analysis of the trial data, we investigated which pretreatment patient characteristics differentially predicted treatment effect in MDFT and CBT, in order to generate hypotheses for future patient-treatment matching.Methods
The predictive value of twenty patient characteristics, in the area of demographic background, substance use, substance-related problems, delinquency, treatment history, psychopathology, family functioning and school or work related problems, was investigated in bivariate and subsequent multivariate linear regression analyses, with baseline to month 12 reductions in cannabis use days and smoked joints as dependent variables.
Results
Older adolescents (17-18 years old) benefited considerably more from CBT, and younger adolescents considerably more from MDFT (p < 0.01). Similarly, adolescents with a past year conduct or oppositional defiant disorder, and those with internalizing problems achieved considerably better results in MDFT, while those without these coexisting psychiatric problems benefited much more from CBT (p < 0.01, and p = 0.02, respectively).
Conclusions
The current study strongly suggests that age, disruptive behavior disorders and internalizing problems are important treatment effect moderators of MDFT and CBT in adolescents with a cannabis use disorder. If replicated, this finding suggests directions for future patient-treatment matching in adolescent substance abuse treatment.