A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification
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- 作者：Jyotiska Chaudhuri1 ; 5 ; Neelanjan Bose1 ; 2 ; 5 ; Jianke Gong3 ; 4 ; David Hall1 ; Alexander Rifkind1 ; Dipa Bhaumik1 ; T. Harshani Peiris1 ; Manish Chamoli1 ; Catherine H. Le1 ; Jianfeng Liu3 ; Gordon J. Lithgow1 ; Arvind Ramanathan1 ; X.Z. Shawn Xu4 ; Pankaj Kapahi1 ; 2 ; 6 ; pkapahi@buckinstitute.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Caenorhabditis elegans ; TRPA1 ; Nrf2 ; α-dicarbonyl stress ; advanced glycation endproducts ; Skn-1 ; diabetic complications ; neuropathy ; aging ; glyoxalase
- 刊名：Current Biology
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：26
- 期：22
- 页码：3014-3025
- 全文大小：4191 K
文摘
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C. elegans with elevated α-dicarbonyls (α-DCs) shows age-related disease pathologies
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TRPA1 is a conserved α-DC sensor and activates Nrf to mediate α-DC detoxification
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Conserved glyoxalases GLO1 and DJ1 mediate effects of the TRPA1-Nrf pathway
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Podocarpic acid activates the TRPA1-Nrf pathway to rescue α-DC-induced pathologies