Use of physiologically based kinetic modeling-facilitated reverse dosimetry of in vitro toxicity data for prediction of in vivo developmental toxicity of tebuconazole in rats

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• 作者：Hequn Li^a ; ^{hequn.li@hotmail.com} ; Mengying Zhang^a ; Jacques Vervoort^c ; Ivonne M.C.M. Rietjens^a ; Bennard van Ravenzwaay^a ; ^b ; Jochem Louisse^a
• 关键词：Physiologically based kinetic modeling ; Reverse dosimetry ; Developmental toxicity ; Embryonic stem cell test ; In vitro&ndash ; in vivo extrapolation ; Tebuconazole
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：266
• 期：Complete
• 页码：85-93
• 全文大小：964 K
• 卷排序：266

文摘

A PBK model was developed that describes tebuconazole kinetics in rats. It was used to predict developmental toxicity based on in vitro toxicity data. The predicted in vivo dose-response data were used to determine a BMDL10. The BMDL10 differed only 3-fold from the reported NOAEL values. BMDL10 value from predicted toxicity data may serve as a POD for risk assessment.