文摘
Nineteen novel polycyclic spiro-fused carbocyclicoxindoles were investigated. Compound 10i displayed inhibitory activities against seven cancer cell lines. 10i arrested cell cycle in G1 phase and induced apoptosis. 10i enhanced the protein levels of cleaved caspase-3, p53, and MDM2. Docking studies showed 10i might block the MDM2-p53 interactions.