文摘
Epigenetically downregulated genes were identified in TAA-treated rat livers. Hist1h2aa, Tmem70, Ube2e2, and Slk showed hypermethylation and mRNA downregulation. Tumor promotion increased downregulation of TMEM70 and UBE2E2 in GST-P+ foci. Downregulation of TMEM70 and UBE2E2 continued to the neoplastic stage. Cell respiration and cell cycling may be carcinogenic targets from early stages.