Computational systems mechanobiology of wound healing

详细信息    查看全文

• 作者：Adriá ; n Buganza Tepole ^{abuganza@purdue.edu}
• 关键词：Wound healing ; Skin ; Remodeling ; Systems biology ; Finite elements
• 刊名：Computer Methods in Applied Mechanics and Engineering
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：314
• 期：Complete
• 页码：46-70
• 全文大小：3740 K
• 卷排序：314

文摘

We model displacements, cells, chemicals, mass fractions and microstructure geometry. We simulate wounds with a monolithic, fully-coupled finite element formulation. Linearization of residuals needs solution of a linear system at integration points. Wounds show contraction and contracture in an annular region surrounding the wound. Initially randomly distributed fibers get aligned in the wound domain.