Mathematical modelling of stretch-induced membrane traffic in bladder umbrella cells
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- 作者：D.E. Moultona ; moulton@maths.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; V. Sulzera ; G. Apodacab ; H.M. Byrnea ; S.L. Watersa
- 关键词：Exocytosis ; Endocytosis ; Mechanosensing ; Uroepithelium
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：409
- 期：Complete
- 页码：115-132
- 全文大小：2243 K
文摘
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Multiscale model developed for vesicle traffic in response to mechanical stimuli.
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Explanation for counterintuitive non-monotonic behaviour observed in experiments.
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In vivo modelling uncovers potential root of bladder disorders in vesicle machinery.
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Clinical potential demonstrated with extensions to mechanical role in innervation.